Well I'm gonna buck the trend of recalcitrance and say that I would learn a new layout - but I'd have to be pretty convinced that it would actually be faster.
But would I'd
really like is this:
http://reviews.designtechnica.com/firstlook61.html
Just think: mouse in left hand, keyboard in right - no need for switching back and forth constantly.
Too bad it's so expensive - and not available in Australia.
Even better would be faultless voice recognition.
Or how about just a cord that I can plug directly into my brain so that I can upload my thoughts
I wonder if that could be done wirelessly

Insert [Humorous quip/Inspirational philosophical musing/Quotation from Zero Wing] here